Volume 24, Issue 5 (Dec - Jan 2021)                   2021, 24(5): 386-397 | Back to browse issues page

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Miraghaee N, Sadeghi A, Mohammadi N. Effect of an Eight-week High-intensity Interval Training Program on Serum Cardiac Troponin I Level of Streptozotocin-induced Diabetic Rats. Journal of Inflammatory Diseases. 2021; 24 (5) :386-397
URL: http://journal.qums.ac.ir/article-1-3092-en.html
1- Department of Sport Sciences, Allameh Qazvini Institute of Higher Education, Qazvin, Iran.
2- Department of Physical Education and Sport Sciences, Faculty of Social Sciences, Imam Khomeini International University, Qazvin, Iran. , sadeghi@soc.ikiu.ac.ir
3- Children Growth Research Center, Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract:   (2460 Views)
Background: One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases. 
Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats. 
Methods: In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’s test were used to analyze the collected data, considering a significance level of P<0.05.
Findings: The induction of diabetes caused a significant increase in blood glucose (P=0.01) and high-sensitive CtnI (P=0.01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0.001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0.591).
Conclusion: he HIIT program can reduce the fasting blood glucose and increase the serum level of high-sensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.
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Type of Study: Research | Subject: physical education

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