Volume 11, Issue 4 (Winter 2008)                   2008, 11(4): 31-35 | Back to browse issues page

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Esmaeili M, Sofiabady M, Rajaei F, Jahany Hashemy H. The effects of prenatal morphine exposure on spatial learning. Journal of Inflammatory Diseases. 2008; 11 (4) :31-35
URL: http://journal.qums.ac.ir/article-1-30-en.html
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Abstract:   (9917 Views)
Abstract Background: Drug abuse during pregnancy is a growing problem in all developed countries worldwide. Maternal drug abuse affects the developing systems and the associated long-term effects can persist untill adulthood, decreasing the rate of their maturation. Objective: To determine the effects of prenatal morphine exposure on spatial learning Methods: Eighteen pregnant rats were divided into morphine, saline, and control groups. Morphine or saline was administrated (S.C) to female rats twice a day (at 12-hr intervals) during the days 11-18 of their gestational period (5 mg/kg morphine for the first 3 days and 10 mg/kg for further 5 days). Pups (P90, n=6) were trained in an 8-arm radial maze apparatus.The data were analyzed statistically using Chi-square test. Findings: The results indicated that prenatal morphine exposure causes a reduction in the time needed to learn these trials however, they needed more time to complete regular trials. Conclusion: Prenatal morphine exposure impairs normal spatial learning.
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Type of Study: Research | Subject: Physiology

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