Volume 9, Issue 3 (Autumn 2005)                   2005, 9(3): 16-21 | Back to browse issues page

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Vafaei A. Assessing the role of rat’s orbitofrontal cortex on sleeping time and duration. Journal of Inflammatory Diseases. 2005; 9 (3) :16-21
URL: http://journal.qums.ac.ir/article-1-719-en.html
, Email: aavaf43@yahoo.com
Abstract:   (8263 Views)
Abstract Background: Sleeping is a biological rhythm controlled by many structures and neurotransmitter systems in brain. Previous evidences suggested that Orbitofrontal Cortex (OFC) is probably involved in sleeping time and the duration. Objective: The aim of this study was to determine the role of OFC area in duration and the time of sleeping by electrical lesions. Methods: Male Wistar rats were used in this experimental study. Rats were surgically implanted bilaterally guided cannulae aimed at the OFC by stereotaxic instrument. One week after recovery, a primary assessment of sleeping duration was made by Angel behavioral method followed by lesioning of OFC using a lesion-maker (electrical electrode). Measuring the behavioral manifestations continued for time and the sleeping duration. Findings: The data found in our study was indicative of a significantly increased sleeping time (P<0.01) following the electrical lesioning of OFC. Conclusion: Our findings showed that OFC of rat’s brain may play an important role in regulating the sleeping process.
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Type of Study: Research | Subject: Physiology

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