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Background: Vomiting after strabismus surgery is a common incidence and may induce many complications. Different drugs may be used as preventive steps. Objective: To compare the effectiveness of droperidol and promethazine in prevention of vomiting following strabismus surgery. Methods: Through an experimental research, 100 patients who were in the age range of 2 to 17 (ASA: 1) and candidated for strabismus surgery were randomly divided into two equal groups (50 cases). As anti-emetic drug, promethazine was infused (0.5 mg/kg/Im) to group A and droperidol (75 mg/kg/Iv) to group B, prior to the surgery. Both groups were followed up for 24 hours after surgery. X² test was used for statistical comparison of two groups. Findings: 7 patients (14%) in group A and 11 (22%) in group B had vomiting. No significant statistical difference was observed between two groups. Conclusion: Promethazine is a good replacement for droperidol in prevention of vomiting, since droperidol is a foreign product, expensive, may not always be available to anesthesiologists and can cause respiratory depression.

Keywords: Strabismus, Vomiting, Promethazine, Droperidol

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