In Press Spring 2022                   Back to the articles list | Back to browse issues page

XML Print


1- Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
2- Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
3- Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;
4- Department of Microbiology, Faculty of Medical Sciences, Islamic Azad University, Kazerun, Iran
5- Department of Bacteriology, Faculty of Medicine, Tabriz University of Medical, Sciences, Tabriz, Iran
6- Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran
7- Department of Virology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , hb.zadeh@gmail.com
Abstract:   (197 Views)
Background: Prostate cancer (PCa), as the fifth leading cause of death, is the second most frequent cancer diagnosis in men worldwide. HPV can potentially contribute to PCa development and chronic inflammation. Human papillomavirus (HPV) infection leads to malignant and benign lesions of the female and male genital areas. The data about the role of HPV in PCa development is contradictory. Our aim of this study is to investigate the frequency of HPV in PCa samples in Tabriz Hospitals.
Methods: This study was conducted in a descriptive cross-sectional manner. Paraffin tissue blocks including 50 patients with primary prostate adenocarcinoma and 50 patients with benign prostatic hyperplasia (BPH) were selected from Tabriz hospitals. All samples were examined for the presence of HPV16/18 by the PCR method.
Results: 3 out of 50 PCa patients are infected with HPV18. None of the benign and malignant prostate samples are infected with HPV 16. Therefore, in our study, there is no connection between HPV and PCa. The HPV-positive samples had a mean age of 61.33+ 11.50.
Conclusions: The result of this research does not support the role of HPV in the development of PCa. Therefore, additional studies are necessary to clarify the possible role of HPV in prostate carcinogenesis.
     
Type of Study: Research | Subject: Virology

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Journal of Inflammatory Diseases

Designed & Developed by : Yektaweb