Volume 26, Issue 1 (Spring 2022)
2022, 26(1): 19-26 |
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Faghany Baladehi R, Bazmani A, Ahangar Oskouee M, Jafari Sales A, Pirzadeh T, Shokouhi B, et al . Frequency of Human Papilloma Virus 16/18 Patients With Prostate Cancer by Polymerase Chain Reaction Method in Hospitals of Tabriz City, Iran. Journal of Inflammatory Diseases. 2022; 26 (1) :19-26
URL: http://journal.qums.ac.ir/article-1-3284-en.html
URL: http://journal.qums.ac.ir/article-1-3284-en.html
Robabeh Faghany Baladehi1 
, Ahad Bazmani1 , Mahin Ahangar Oskouee2 , Abolfazl Jafari Sales3 , Tahereh Pirzadeh4 , Behrouz Shokouhi5 , Mohammad Yousef Memar1 , Hossein Bannazadeh Baghi * 6
, Ahad Bazmani1 , Mahin Ahangar Oskouee2 , Abolfazl Jafari Sales3 , Tahereh Pirzadeh4 , Behrouz Shokouhi5 , Mohammad Yousef Memar1 , Hossein Bannazadeh Baghi * 6
1- Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2- Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3- Department of Microbiology, School of Medical Sciences, Islamic Azad University, Kazerun, Iran.
4- Department of Bacteriology, School of Medicine, Tabriz University of Medical, Sciences, Tabriz, Iran.
5- Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.
6- Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , hbannazadeh@tbzmed.ac.ir
2- Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
3- Department of Microbiology, School of Medical Sciences, Islamic Azad University, Kazerun, Iran.
4- Department of Bacteriology, School of Medicine, Tabriz University of Medical, Sciences, Tabriz, Iran.
5- Department of Pathology, Tabriz University of Medical Sciences, Tabriz, Iran.
6- Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , hbannazadeh@tbzmed.ac.ir
Abstract: (1740 Views)
Background: Prostate cancer (PCa), as the fifth leading cause of death, is the second most common cancer diagnosis in men worldwide. Human papillomavirus (HPV) can potentially contribute to PCa development and chronic inflammation. HPV infection leads to malignant and benign lesions in the genital areas of men and women. The data on the role of HPV in PCa development is contradictory.
Objective: This study aims to investigate the frequency of HPV in PCa samples in hospitals in Tabriz City, Iran.
Methods: This study was conducted in a cross-sectional descriptive manner. Paraffin tissue blocks including 50 patients with primary prostate adenocarcinoma and 50 patients with benign prostatic hyperplasia (BPH) were selected from Tabriz hospitals. All samples were examined for the presence of HPV16/18 by the polymerase chain reaction (PCR) method.
Findings: 3 out of 50 PCa patients are infected with HPV18. None of the benign and malignant prostate samples are infected with HPV 16. Therefore, in our study, no connection exists between HPV and PCa. The Mean±SD age of HPV positive samples was 61.33±11.50 years.
Conclusion: The result of this research does not support the role of HPV in the development of PCa. Therefore, additional studies are necessary to clarify the possible role of HPV in prostate carcinogenesis.
Objective: This study aims to investigate the frequency of HPV in PCa samples in hospitals in Tabriz City, Iran.
Methods: This study was conducted in a cross-sectional descriptive manner. Paraffin tissue blocks including 50 patients with primary prostate adenocarcinoma and 50 patients with benign prostatic hyperplasia (BPH) were selected from Tabriz hospitals. All samples were examined for the presence of HPV16/18 by the polymerase chain reaction (PCR) method.
Findings: 3 out of 50 PCa patients are infected with HPV18. None of the benign and malignant prostate samples are infected with HPV 16. Therefore, in our study, no connection exists between HPV and PCa. The Mean±SD age of HPV positive samples was 61.33±11.50 years.
Conclusion: The result of this research does not support the role of HPV in the development of PCa. Therefore, additional studies are necessary to clarify the possible role of HPV in prostate carcinogenesis.
Keywords: Prostate cancer (PCa), Human papillomavirus (HPV), HPV16, HPV18, Carcinoma, Benign prostatic hyperplasia (BPH)
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Journal of Inflammatory Diseases
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