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1- Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2- Blood Borne Infections Research Center, Academic Center for Education, Culture and Research (ACECR), Razavi Khorasan Branch, Mashhad, Iran.
3- Department of parasitology and mycology, Faculty of medicine, Mashhad university of medical sciences, Mashhad, Iran.
4- Institute for Science and Technology in Medicine, University of Keele, Guy Hilton Research Centre, Thornburrow Drive, Stoke on Trent, Staffordshire ST4 7QB, UK
5- Metabolic Syndrome Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. , ghayourm@mums.ac.ir
Abstract:   (127 Views)

Background: Heat shock protein 27 (HSP27) is found in several cell types of adults, such as cardiomyocytes, and endothelial cells. It is expressed in response to different cellular stress conditions. HSP27 decreases the levels of reactive oxygen species (ROS) and dyslipidemia is closely associated with increased endothelial production of ROS. Higher serum HSP27 antigen and anti-HSP27 antibody have been reported in patients with unstable angina and myocardial infarction

Methods: This population based case-control study has been done in 2018. We have investigated serum anti-HSP27 antibody titers in all participants with dyslipidemia from the MASHAD study (n=8141) and those who were healthy in terms of dyslipidemia (n=1637) using an in-house enzyme-linked immune sorbent assay (ELISA) in individuals with dyslipidemia.

Result: Anti-Hsp27 titers were significantly lower in individuals with dyslipidemia compared to those without dyslipidemia (P=0.036).
Conclusion: In conclusion, our results revealed that the anti-HSP27 antibody titer in the participants with dyslipidemia was lower than in the negative group. However, there may be a confounding effect of drug therapy. In one subgroup of dyslipidemic subjects, we observed lower anti-HSP27 antibody titers in patients who had been treated with some drugs (statins or corticosteroids, NSAIDs, or anti-diabetic and anti-hypertensive) compared to those who had not been treated with these drugs.

     
Type of Study: Research | Subject: Biochemistry

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