Volume 25, Issue 3 (Autumn 2021)
2021, 25(3): 169-174 |
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Najafipour R, Rashvand Z, Taherkhani K, Chamanara S, Abotorabi S, Moghbelinejad S. Association of Two MMP-8 Gene Polymorphisms With Recurrent Pregnancy Loss in Iranian Women. Journal of Inflammatory Diseases. 2021; 25 (3) :169-174
URL: http://journal.qums.ac.ir/article-1-3273-en.html
URL: http://journal.qums.ac.ir/article-1-3273-en.html
Reza Najafipour1 
, Zahar Rashvand1, Khadijeh Taherkhani1, Solmaz Chamanara2, Shokoh Abotorabi2 , Sahar Moghbelinejad * 3
, Zahar Rashvand1, Khadijeh Taherkhani1, Solmaz Chamanara2, Shokoh Abotorabi2 , Sahar Moghbelinejad * 3
1- Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical science, Qazvin, Iran.
3- Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. , smoghbelinejad@qums.ac.ir
2- Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical science, Qazvin, Iran.
3- Research Institute for Prevention of Non-communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. , smoghbelinejad@qums.ac.ir
Abstract: (569 Views)
Background: It has been reported that less than 5% of women experience recurrent pregnancy loss (RPL). different matrix metalloproteinases (MMPs) have proteolysis function with a main role in the stable development of the fetus.
Objective: This study aims to assess the associations between two single nucleotide polymorphisms (rs2509013 C>T and rs11225395 G>A) of MMP-8 gene and RPL among 130 Iranian women with a history of RPL and 130 controls.
Methods: Genotyping of the MMP-8 gene was done for the two polymorphisms by using Sanger sequencing method.
Results: High frequency of AA genotype (OR: 2.5, 95%CI:1.02-4.1, P<0.01) and A allele (OR:1.95, 95% CI:0.95-3.1, P<0.001) of rs11225395 G>A polymorphism in patients compared to controls. This high frequency was also reported in the haplotypes and combined genotypes of polymorphism.
Conclusion: The MMP-8 gene may be involved in RPL risk and is a potential biomarker for RPL susceptibility.
Objective: This study aims to assess the associations between two single nucleotide polymorphisms (rs2509013 C>T and rs11225395 G>A) of MMP-8 gene and RPL among 130 Iranian women with a history of RPL and 130 controls.
Methods: Genotyping of the MMP-8 gene was done for the two polymorphisms by using Sanger sequencing method.
Results: High frequency of AA genotype (OR: 2.5, 95%CI:1.02-4.1, P<0.01) and A allele (OR:1.95, 95% CI:0.95-3.1, P<0.001) of rs11225395 G>A polymorphism in patients compared to controls. This high frequency was also reported in the haplotypes and combined genotypes of polymorphism.
Conclusion: The MMP-8 gene may be involved in RPL risk and is a potential biomarker for RPL susceptibility.
Article number: 5
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