Association of rs11225395 polymorphism of MMP-8 gene with recurrent pregnancy loss among Iranian women

Najafipour, Reza; Rashvand, Zahar; Taherkhani, Khadijeh; Chamanara, Solmaz; Abotorabi, Shokoh Sadat; Moghbelinejad, Sahar

Volume 25, Issue 3 (In Press_ Autumn 2021) 2021, 25(3): 0-0 | Back to browse issues page

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Najafipour R, Rashvand Z, Taherkhani K, Chamanara S, Abotorabi S S, Moghbelinejad S. Association of rs11225395 polymorphism of MMP-8 gene with recurrent pregnancy loss among Iranian women. Journal of Inflammatory Diseases. 2021; 25 (3)
URL: http://journal.qums.ac.ir/article-1-3273-en.html

Association of rs11225395 polymorphism of MMP-8 gene with recurrent pregnancy loss among Iranian women

Reza Najafipour¹

, Zahar Rashvand¹, Khadijeh Taherkhani¹, Solmaz Chamanara², Shokoh Sadat Abotorabi²

, Sahar Moghbelinejad ^*

1- Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical science, Qazvin, Iran.
3- Research Institute for Prevention of Non-Communicable Diseases, Cellular and Molecular Research Centre, Qazvin University of Medical Sciences, Qazvin, Iran. , smoghbelinejad@qums.ac.ir

Abstract: (174 Views)

It is assessment that fewer than 5% of women experience recurrent pregnancy loss (RPL). Among these, metalloproteinases are important. Different Matrix metalloproteinases (MMPs) have proteolysis function and have main role in the stable development of the fetus. In this research, the associations between single nucleotide polymorphisms (SNPs) of MMP-8 gene and RPL was studied among 130 Iranian women with a history of RPL and 130 controls.Genotyping of the MMP-8 gene was done for two polymorphisms of rs2509013 C>T and rs11225395 G>A by using sanger sequencing. Our results showed high frequency of AA genotype (OR: 2.5 CI:(1.02-4.1) ) (P<0.01) and A allele (OR:1.95 CI:(0.95-3.1)) (P <0.001) of rs11225395 G>A polymorphism among the RPL patients in comparison to controls. Also, these trends were maintained in the haplotype and genotype combination analyses. In conclusion, we can say MMP-8 may be involve in RPL risk and is a potential biomarker for RPL susceptibility.

Article number: 5

Keywords: Recurrent pregnancy loss (RPL), Matrix metalloproteinase (MMP), MMP-8, Polymorphism

Type of Study: Research | Subject: Genetics

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