Volume 25, Issue 4 (In Press_ Winter 2021 2021)                   2021, 25(4): 5-5 | Back to browse issues page

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Lalooha F, Elmizadeh K, Rahimi S, Movahed F, Chegini V. Investigating the Relationship between serum CRP, Ferritin levels and Gestational Diabetes in Pregnant Women in Qazvin. Journal of Inflammatory Diseases. 2021; 25 (4) :5-5
URL: http://journal.qums.ac.ir/article-1-3263-en.html
1- Department of Obstetrics and Gynecology, Clinical Research Development Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran
2- Fellowship of Oncology, Department of Obstetrics and Gynecology, Clinical Development and Research Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran. , p.elmizadeh@gmail.com
3- Department of Obstetrics and Gynecology, Clinical Development and Research Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
4- Fellowship of laparoscopy, Department of Obstetrics and Gynecology, Clinical Development and Research Unit, Kowsar Hospital, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract:   (107 Views)
Background: The aim of this study was to compare the serum levels of CRP and ferritin in the first trimester of normal and abnormal pregnancies complicated with gestational diabetes to determine if they have any predictive value in the diagnosis of gestational diabetes.
Materials and Methods: this prospective cohort study was carried out on 300 pregnant women attending in theprenatal clinic of the Qazvin Kosar Hospital between 2017-2018. Based on Carpenter and Constant criteria, an oral glucose tolerance test with 75 g glucose was undertaken to diagnose gestational diabetes, and the serum levels of CRP and ferritin were also measured in all the patients in the first trimester. Data was analyzed using SPSS 24 software. P < 0.05 was considered statistically significant
Results: 40 patients were found to have gestational diabetes. Although the results were not statistically significant, the levels of CRP and ferritin were slightly higher in patients with gestational diabetes. Regarding the ROC curve, BMI was able to predict the incidence of gestational diabetes (72.5% sensitivity, 53.1% specificity, P=0.023). The higher values of BMI and CRP levels in the first trimester were also significantly associated with macrosomia, able to predict macrosomia with 75% sensitivity, 73.6% specificity for BMI (P = 0.005) and 87.5 % sensitivity, 58.1% specificity for BMI.
Conclusion:  There was no correlation between CRP and ferritin levels and gestational diabetes in the first trimester of pregnancy. BMI before pregnancy was the only variable related to gestational diabetes. Increased values of both CRP and BMI were associated with fetal macrosomia.
     
Type of Study: Clinical trial | Subject: Obsterics & Gynecology

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