Volume 25, Issue 3 (In Press_ Autumn 2021)                   2021, 25(3): 0-0 | Back to browse issues page

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Sheikhdavoodi N, Gheraati M, Hashemipour S, Badri M, Rastgoo N, Shokri A, et al . Hyponatremia at admission in hospitalized patients with COVID-19: Risk factors and impact on prognosis. Journal of Inflammatory Diseases. 2021; 25 (3)
URL: http://journal.qums.ac.ir/article-1-3245-en.html
1- Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
2- Metabolic Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran , maryam.gheraati22@gmail.com
3- Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
Abstract:   (927 Views)
Background: Electrolyte disorders, particularly hyponatremia, have been reported in a considerable number of COVID-19 patients.
Objective: The current study aims to evaluate the predisposing factors, symptoms, and prognosis of hyponatremia patients with the COVID-19 disease.
Methods: In this retrospective cohort study, 467 patients with COVID-19 were divided into the following 4 groups: isonatremia, mild hyponatremia, moderate hyponatremia, and severe hyponatremia. Symptoms, laboratory findings, and prognosis were compared among these groups. The risk factors for the occurrence of moderate/severe hyponatremia and independent association of hyponatremia with mortality were investigated using logistic regression analysis.
Findings: Hyponatremia was diagnosed in 60% of the patients. The prevalence of mild, moderate, and severe hyponatremia was 80.7%, 15.1%, and 4.2%, respectively. The severity of the clinical symptoms and level of hypoxia in sodium groups showed no significant difference between the groups. White blood cells count was significantly higher and lymphocyte percent was significantly lower in hyponatremia groups compared to isonatremia group. The history of chronic lung disease was an independent risk factor for the occurrence of moderate/severe hyponatremia (adjusted OR=5.11, 95%CI, 1.72-15.2, p=0.003). After adjustment to different risk factors for poor prognosis, moderate/severe hyponatremia remained a significant independent risk factor for mortality (OR=2.58, 95%CI, 1.13-5.88, P=0.024).
Conclusion: Hyponatremia is prevalent in COVID-19 patients. However, it is not definitely associated with severity of COVID-19 disease at admission. Moderate/severe hyponatremia is associated with higher mortality rate despite the similarity of disease severity between sodium groups.
Article number: 1
     
Type of Study: Research | Subject: Infectious Disease

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