Volume 25, Issue 2 (In Press_ Summer 2021)                   2021, 25(2): 0-0 | Back to browse issues page

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Arad B, Chegini V, Talati N, Homaei A, Saffari F. High frequency of nephropathy among the Iranian children and adolescents with type 1 diabetes. Journal of Inflammatory Diseases. 2021; 25 (2)
URL: http://journal.qums.ac.ir/article-1-3237-en.html
1- Assistant Professor of Pediatric Nephrology Department of Pediatrics, School of Medicine Children Growth Research Center, Research Institute for Prevention of Non- Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, Clinical Research Development Unit, Qods Hospital, Qazvin University of Medical Sciences.
2- Assistant Professor of Pediatric Intensive Care Department of Pediatrics, School of Medicine Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences.
3- Student Research Committee, medical science, Qazvin University of Medical Sciences, Qazvin, Iran.
4- Student of Medicine, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
5- Associate Professor of Pediatric Endocrinology, Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. , drfa_saffari@yahoo.com
Abstract:   (217 Views)
Background: Type 1 diabetes (T1D) is one of the most common chronic diseases in children, and nephropathy is a serious microvascular complication of T1D, which is associated with high mortality and morbidity. This study aimed to investigate the prevalence of diabetic nephropathy and comorbidities in children with T1D.
Methods: This cross-sectional study was conducted on 208 children (aged 1–18 years old) with T1D referred to the Qazvin endocrinology clinic during 2017–2019. Anthropometric, demographic, laboratory, comorbidities data were collected.
Results: The mean age at diagnosis of diabetes was 7.59 years, and the mean HbA1c level of the study subjects was 8.68 ± 1.42. Out of 208 diabetic patients, 64 (30.7%) had diabetic nephropathy, of which 53 (25.5%) had microalbuminuria, and 11 (5.3%) had macroalbuminuria. Among the studied diabetic patients, 30 (14.45%) had hypothyroidism, 12 patients (5.8%) had celiac disease, and 14 patients (6.7%) had anemia. Retinopathy was not found in any of the patients. Moreover, variables such as the duration of diabetes, puberty status, mean HbA1c levels, and age were significantly associated with diabetic nephropathy (p <0.05).
Conclusion: In present study, 30.7% patients  had diabetic nephropathy, of which  25.5% and  5.3% had microalbuminuria and macroalbuminuria, respectively. In addition, there was a significant relationship between puberty status and nephropathy (p <0.001). Also, mean HbA1c levels were significantly higher in patients with macroalbuminuria, which may corroborate the role of metabolic control of diabetes in the development of albuminuria.
Type of Study: Research | Subject: endocrinology

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