Accepted Articles
Back to the articles list |
Back to browse issues page
1- Department of physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
2- Department of physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran , mohasofi@yahoo.com
2- Department of physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran , mohasofi@yahoo.com
Abstract: (81 Views)
Background: Norhraman is an alkaloid that can damage the nervous system.
Objectivities: This experimental study aimed to investigate the effect of prenatal norharman exposure on the seizure severity of adult rats.
Methods: 36 Wistar rats were randomly divided into 3 groups: 1. control 2. Sham (solvent) 3. Norharman (1000 ug/kg). Sham and norharman groups were treated once daily for 8 to 18 of the fetal period. 2 months after birth, the kindling was performed by daily injection of Pentylenetetrazol (30 mg/kg), and then the seizure behavior was recorded for about 30 minutes. Data were analyzed using ANOVA and Tukey post hoc tests.
Findings: The data showed that the administration of norharman in the fetal period was increased the seizures response to PTZ which was significant in female rats (P <0.05).
Conclusion: According to these findings, the severity of seizures increases in subjects who have been exposed to norharman during the prenatal period.
Objectivities: This experimental study aimed to investigate the effect of prenatal norharman exposure on the seizure severity of adult rats.
Methods: 36 Wistar rats were randomly divided into 3 groups: 1. control 2. Sham (solvent) 3. Norharman (1000 ug/kg). Sham and norharman groups were treated once daily for 8 to 18 of the fetal period. 2 months after birth, the kindling was performed by daily injection of Pentylenetetrazol (30 mg/kg), and then the seizure behavior was recorded for about 30 minutes. Data were analyzed using ANOVA and Tukey post hoc tests.
Findings: The data showed that the administration of norharman in the fetal period was increased the seizures response to PTZ which was significant in female rats (P <0.05).
Conclusion: According to these findings, the severity of seizures increases in subjects who have been exposed to norharman during the prenatal period.
Type of Study: Research |
Subject:
Physiology
Send email to the article author
Contact Information
Journal of Inflammatory Diseases
Shahid Bahonar Blvd, Qazvin University of Medical Sciences, Qazvin, Iran
Shahid Bahonar Blvd, Qazvin University of Medical Sciences, Qazvin, Iran
Journal Tel: +98 28 33357036
Website: http://journal.qums.ac.ir
E-mail: jresearchdpt@qums.ac.ir
