1- Department of Physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Department of Physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran. , mohasofi@yahoo.com
Abstract: (1975 Views)
Background: Norhraman is an alkaloid that can damage the nervous system.
Objective: This experimental study aimed to investigate the effects of prenatal norharman exposure on seizure severity in adult rats.
Methods: A total of 36 Wistar rats were randomly divided into 3 groups as follows: Control, sham (solvent), and norharman (1000 ug/kg). The sham and norharman groups were treated once daily for 8-18 of the fetal period. 2 months after birth, kindling was performed by the daily injection of Pentylenetetrazol (PTZ) (30 mg/kg); then, the seizure behavior was recorded for approximately 30 minutes. The obtained data were analyzed using Analysis of Variance (ANOVA) and Tukey’s posthoc test.
Results: The present study data indicated that administrating norharman in the fetal period increased seizure responses to PTZ, i.e., significant in the examined female rats (P<0.05).
Conclusion: According to the current research findings, the severity of seizures increases in subjects who have been exposed to norharman during the prenatal period.
Type of Study:
Research |
Subject:
Physiology