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1- Department of physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
2- Department of physiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran , mohasofi@yahoo.com
Abstract:   (81 Views)
Background: Norhraman is an alkaloid that can damage the nervous system.
Objectivities: This experimental study aimed to investigate the effect of prenatal norharman exposure on the seizure severity of adult rats.
Methods: 36 Wistar rats were randomly divided into 3 groups: 1. control 2. Sham (solvent) 3. Norharman (1000 ug/kg). Sham and norharman groups were treated once daily for 8 to 18 of the fetal period. 2 months after birth, the kindling was performed by daily injection of Pentylenetetrazol (30 mg/kg), and then the seizure behavior was recorded for about 30 minutes. Data were analyzed using ANOVA and Tukey post hoc tests.
Findings: The data showed that the administration of norharman in the fetal period was increased the seizures response to PTZ which was significant in female rats (P <0.05).
Conclusion: According to these findings, the severity of seizures increases in subjects who have been exposed to norharman during the prenatal period.
     
Type of Study: Research | Subject: Physiology

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