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1- Arak University , N-Darbandi@araku.ac.ir
2- Arak University
Abstract:   (96 Views)
Background: Zinc oxide NPs have irreversible effects on the nervous system, memory and learning.
Objective: The aim of this study was to investigate the effect of pentoxifylline on memory impairment, CA1 hippocampal pyramidal cells and blood serum antioxidant enzymes in male rats treated with zinc oxide NPs.
Methods: Male Wistar rats were divided into control groups, zinc oxide NPs (1.25 mg/kg), pentoxifylline (50 mg/kg) and pentoxifylline with zinc oxide NPs. In all groups, saline, zinc oxide NPs, and pentoxifylline were injected intraperitoneally 30 minutes before training. In the co-treatment group, pentoxifylline was injected one hour before injection of Zno NPs. After the behavioral test, animal brains were fixed and the number of healthy neurons in the CA1 region of the hippocampus was counted. In all groups, malondialdehyde levels, total antioxidant power, superoxide dismutase levels, and glutathione peroxidase in blood serum were measured.

Findings: Zinc oxide nanoparticles decreased memory and the number of healthy neurons in the CA1 region of the hippocampus and increased oxidative stress in blood serum compared to the control group. In the co- treatment group, the use of pentoxifylline improved the above factors and reached them to the control group. Pentoxifylline alone had no significant effect on the above factors compared to the control group.
Conclousion: ZnO NPs may decrease the memory retrieval, and cause cell death in the pyramidal neurons of the CA1 region of the hippocampus by increasing the oxidative stress. pentoxifylline, as a potent antioxidant can prevent the harmful effects of ZnO NPs.
     
Type of Study: Research | Subject: Physiology

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