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Background: Proteinuria is the most important factor in dignosis and management of preeclamptic patients. The use of a method providing rapid diagnosis of preeclampsia is of prime importance and critical to immediate treatment. Objective: To measure the protein content of a 24-hour urine samples by determining protein/creatinine ratio in a random urine sample obtained from a pregnant women suspected of preeclampsia. Methods: This was a cross-sectional study carried out in Kosar hospital, Qazvin, Iran, during 2003-2004. The subjects were 50 pregnant women with gestationl age³ 20 weeks and blood pressure³140/90. Following admission, the protein content of a 24-hour urine sample was measured and later, a random urine sample collected for determination of protein/creatinine ratio. Correlation coefficient between 24-hour proteinuria and protein/creatinine ratio was further calculated. Findings: Among 50 pregnant women, 12 cases had a proteinuria>300mg/day and 38 with proteinuria<300mg/day. Regarding the results of our study, a protein/creatinine ratio of £0.25 was compatible with 24-hour proteinuria<300mg and similarly, a protein/creatinine ratio of >0.25 with 24-hour proteinuria>300mg (r=0/99, p<0/001). Sensitivity, specificity, and the positive/negative predictive value for this ratio was 98% with an accuracy of 96%. Conclusion: Determination of protein/creatinine ratio of a random urine sample could predict significant proteinuria(>300mg/24h).

Keywords: Keywords: Pre-eclampsia, Proteinuria, Creatinine

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