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The effect of cinnamon on glucose concentration of diabetic rats in presence or absence of insulin
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| N. Gheibi * , MR. Parvizi , H. Jahani Hashemi |
| , Gheibi@bb.ut.ac.ir |
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Abstract: (8544 Views) |
| Abstract
Background: Some plants and their aqueous extracts are used as traditional treatments for diabetes. Cinnamon as a preferred candidate shows anti-diabetic and hypoglycemic effects.
Objective: To determine the effect of cinnamon extract on blood glucose level of diabetic rats.
Methods: The present work was an experimental study in which seventy NMRI male rats (180-250gr) were divided into 2 major groups named as normal and diabetic group. Normal group was further subdivided as control, cinnamon and insulin subgroups in which the latter two received suspensions of cinnamon 60mg/kg per day and intraperitoneal injections of insulin (5μg/kg), respectively. In four diabetic subgroups, diabetes was induced by ip injection of streptozotocin (40mg/kg). These groups were marked as diabetic control, diabetic/cinnamon, diabetic/insulin and cinnamon plus insulin subgroups.
Findings: Our results showed that the oral administration of cinnamon had not significant effect on normal cinnamon subgroup. Insulin injection in normal rats reduced glucose concentration from 99.1 to 52.1 mg/dl. Glucose concentration in diabetic groups with treatment of cinnamon, Insulin and both of them were measured 121.6, 69.6 and 41.4 mg/dl, respectively. Reduction of glucose concentration in these subgroups show asignificant change in comparison with control diabetic subgroup, 366.5 mg/dl (p<0.001).
Conclusion: Cinnamon can reduce blood glucose concentration in diabetic rats and it seems that the cinnamon effect to be probably linked with potentiating action of cinnamon on insulin. |
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| Keywords: Keywords: Blood Glucose, Cinnamon, Insulin, Diabetes Mellitus |
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Full-Text [PDF 146 kb]
(1564 Downloads)
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Type of Study: Research |
Subject:
Physioligy
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