Volume 3, Issue 4 (Winter 2000)                   J Qazvin Univ Med Sci 2000, 3(4): 35-44 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mortazavi R, Derakhshan F. Effects of aging on Cholinergic system of rat isolated ileum. J Qazvin Univ Med Sci. 2000; 3 (4) :35-44
URL: http://journal.qums.ac.ir/article-1-580-en.html
Abstract:   (7100 Views)
Background: Aging is associated with changes in gastrointestinal functions. Objective: To determine the effects of aging on the cholinergic system of rat isolated ileum. Methods: In this research, isolated ileum from 9 to 11 days, 2 months, 6 months, and one year old male albino rats (N?6) were prepared and their contraction responses were characterized by determining the ED50 of acetylcholine. Findings: According to results, the sensitivity of m-AchRs were decreased in relation to age (The ED50 of acetylcholine in 9-11 days, 2 months, 6 months, and 1 year old rats were 3.46×10^-5, 6.58×10^-5, 1.34×10^-5 and 1.018×10^-4 respectively). The maximum response was observed in 6 months old rats. Conclusion: The decline of responsiveness appears to be the result of age-related changes in cholinergic neuromuscular transmission.
Keywords: Aging, Cholinergic, Rat, Ileum
Full-Text [PDF 1333 kb]   (1496 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2008/11/3

Add your comments about this article : Your username or Email:

© 2019 All Rights Reserved | The Journal of Qazvin University of Medical Sciences

Designed & Developed by : Yektaweb