Volume 3, Issue 3 (Autumn 1999)                   J Qazvin Univ Med Sci 1999, 3(3): 5-12 | Back to browse issues page

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Afshari A, Holme E. Effect of Streptokinase immune complex on activation of the complement and interaction with erythrocytes. J Qazvin Univ Med Sci. 1999; 3 (3) :5-12
URL: http://journal.qums.ac.ir/article-1-554-en.html
Abstract:   (9568 Views)
Background: One of major disadvantages of streptokinase, a commonly administered thrombolytic agent, is provocation of hypersensitivity. Objective: To determine interactions of the complement and erythrocytes with streptokinase. Methods: The interactions were studied by the measurement of complement activation products C1S: C1:INH and C3b-P, using modified techniques by Auda et al (1990). The kinetics and dose response of streptokinase immune complexes binding to erythrocytes were studied by flowcytometry. Findings: The findings indicated that the binding of ICs to Es depended significantly on the extent of complement activation (P<0.001) and ICs dose of ICs (P<0.001). Conclusion: It can be concluded that the complement system and Es have a central role in preventing the hypersensitivity reactions, in particular type III (Immune complex disease).
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Type of Study: Research | Subject: Microbiology

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