Volume 5, Issue 4 (Winter 2002)                   J Qazvin Univ Med Sci 2002, 5(4): 15-23 | Back to browse issues page

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Heidari M, Asadipour A, Ghayoor M. Evaluation of analgesic and ulcerogenic effect of Methanolic extract of Matricaria Chamomilla L. J Qazvin Univ Med Sci. 2002; 5 (4) :15-23
URL: http://journal.qums.ac.ir/article-1-450-en.html
Abstract:   (14049 Views)
Background: Matricaria chamomilla L has a particular position as analgesic, anxiolitic and carminative in traditional medicine. Objective: To evaluate the analgesic and ulcerogenic effect of methanolic extract of matricaria chamomilla L. Methods: This plant was extracted by suxhlet and percolation methods by methanol 80%. The extract was then concentrated and the weight of direct extract was determined and dissolved in normal salin to produce a different desired concentration. The analgesic effect was evaluated by formalin and hot-plate test in mice and the ulcerogenic effect was studied in rats. Findings: The results indicated that the analgesic effect of percolation extract is higher than the suxhlet extract (P<0.01). The percolation extract with dose of 200 mg/kg which was injected intra-peritoneally to mice and its analgesic effect evaluated by hot-plate test revealed a significant effect to normal salin (P<0.05). The extract did not induce gusteric ulcer. Conclusion: The results showed that the analgesic effect of the extract was not mediated via opiate system and probably meditated via its anti-inflammatory effect.
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Type of Study: Research | Subject: Pharmacology

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