Volume 9, Issue 4 (Winter 2006)                   J Qazvin Univ Med Sci 2006, 9(4): 25-29 | Back to browse issues page

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Jafari H, .Abbassi A, .Miri S, Shahidi M. Effect of Allium sativum L. aqueous extract on contraction power of isolated atrium from rats following administration of adrenaline. J Qazvin Univ Med Sci. 2006; 9 (4) :25-29
URL: http://journal.qums.ac.ir/article-1-314-en.html
1- , Email: hJafari@qums.ac.ir
Abstract:   (8149 Views)

¯Abstract Background: Synthetic drugs, although very effective, have their own side effects. Recently, herbal plants have received more attention to avoid the unpleasant effects of synthetic agents. Objective: To investigate the effects of garlic aqueous extract on contraction power of isolated atrium from male rats following administration of adrenalin. Methods: Male rats (Spirague Dawley, Albino, 200-250 gr) were divided into 7 groups as follows: Control, adrenalin, garlic extract (10 mg/kg, 20 mg/kg, and 40mg/kg), Propranolol and Propranolol plus garlic extract at a single concentration of 40 mg/kg. Later the contraction power was recorded using a physiograph set. Findings: Garlic extract at all three concentrations used in our study caused a reduction of atrial contraction power in adrenalin group. When the degree of contraction power reduction was compared between garlic extract (40mg/kg) and garlic extract plus Propranolol groups, no statistically significant difference found. Conclusion: Atrial contraction power decreased in presence of garlic aqueous extract and the degree of reduction was significant in both low and high doses, statistically.

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Type of Study: Research | Subject: Physiology

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