Volume 22, Issue 1 (Apr - May 2018)                   J Qazvin Univ Med Sci 2018, 22(1): 4-12 | Back to browse issues page

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Bahman A, Abotorabi S, Dabaghi Ghale T, Javadi A. Comparing effect administration calcium-vitamin D and metformin in regulating menstrual cycle in women with polycystic ovarian syndrome. J Qazvin Univ Med Sci. 2018; 22 (1) :4-12
URL: http://journal.qums.ac.ir/article-1-2474-en.html
1- Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical Science, Qazvin, Iran
2- Department of Obstetrics and Gynecology, School of Medicine, Qazvin University of Medical Science, Qazvin, Iran , shabotorabi@qums.ac.ir
3- Department of Social Science, School of Medicine, Qazvin University of Medical Science, Qazvin, Iran
Abstract:   (6789 Views)
Background: Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrinological gynecologic disorders of reproductive aged women. Its complications contains various clinical symptoms including irregular menstruation, hirsutism, increasing risk of endometrial hyperplasia, diabetes II, neoplasia, and infertility.
Objective: This study aimed to compare the effect of two drugs metformin and calcium-D in regulating menstrual abnormalities.
Methods: This randomized single blind clinical trial was done in Kosar hospital in 2013. In this study, 60 reproductive aged women 20-40 ages with PCOS were selected according to Rotterdam criteria and randomly divided into two groups of 30 subjects. The first group was given daily a calcium-D tablet (1000 mg calcium, vitamin D 400 IU) and second group were given metformin tablet 500 mg 3 times per day for 6 months. At the end of study, ovarian sonography, change of mean interval menstrual cycles and level of blood testosterone were recorded. All data were analyzed with T-test and repeated Measures.
Findings: Mean menstrual cycle in the first and end of the study in the Ca-D and metformin groups were respectively 56.45±33.35 and 53.71±33.12 days that were not statistically significant. After treatment, the ovarian volume was decreased to 51% and 49% in the Ca-D and metformin groups respectively in sonography that there was no significant between them.
Conclusion: The findings demonstrated that administration of these two drugs were similar function in regulate the menstrual cycle and reduce the volume of the ovaries in women with PCOS.
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Type of Study: Research | Subject: Obsterics & Gynecology

1. Fritz M, Speroff L. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelphia: Lippincott Williams & Wilkins; 2014. 500.
2. Rotterdam ESHRE/ASRM – Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risk related to polycystic ovary syndrome. Fertile Steril 2004; 81(1): 19-25. [DOI] [PubMed]
3. Pandis D, Balaris C, Farmakiotis D, Rousso D, Kourtis A, Balaris V, et al. Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clinc Chem 2005; 51(9): 1691-7. [DOI] [PubMed]
4. Firouzabadi Rd, Aflatoonian A, Modarresi S, Sekhavat L, Mohammad Taheri S. Therapeutic effects of calcium & vitamin D supplementation in women with PCOS. Complement Ther Clin Pract 2012; 18(2): 85-8. [DOI] [PubMed]
5. Hahn S, Hasel horst U, Tan S, Quabeck B, Schmid M, Rosele S, et al. Low serum 25- hydroxy vitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006; 114(10): 577- 83. [DOI] [PubMed]
6. Schorge JO, Schaffer JI, Halvorson LM, Hoffman BL, Bradshaw KD, Cunningham F et al. Williams Gynecology. 2nd ed New York: McGraw-Hill; 2008. 395.
7. Moini A, Shirzad N, Ahmadzadeh M, Hosseini R, Hosseini L, Sadatmahalleh SJ. Comparison of 25-hydroxyvitamin D and calcium levels between polycystic ovarian syndrome and normal women. Int J Fertil Steril 2015; 9(1): 1-8. [PubMed]
8. Ghazeeri G, Abbas HA, Skaff B, Harajly S, Awwad J. Inadequacy of initiating rosuvastatin then metformin on biochemical profile of polycystic ovarian syndrome patients. J Endocrinol Invest 2015; 38(6): 643-51. [DOI] [PubMed]
9. Durá-Travé T, Gallinas-Victoriano F, Chueca-Guindulain MJ, Berrade-Zubiri S. Prevalence of hypovitaminosis D and associated factors in obese Spanish children. Nutr Diabetes 2017; 7(3): e248. doi: 10.1038/ nutd.2016.50. [PubMed]
10. Kotsa K, Yavropoulou MP, Anastasiou O, Yovos JG. Role of vitamin D treatment in glucose metabolism in polycystic ovary syndrome. Fertil Steril 2009; 92(3): 1053-8. [DOI] [PubMed]
11. Rashidi B, Haghollahi F, Shariat M, Zayeri F. The effects of calcium-vitamin D and metformin on polycystic ovary syndrome: a pilot study. Taiwan J Obstet Gynecol 2009; 48(2): 142-7. [DOI] [PubMed]
12. Gupta T, Rawat M, Gupta N, Arora S. Study of effect of vitamin D supplementation on the clinical, hormonal and metabolic profile of the PCOS women. J Obstet Gynaecol India 2017; 67(5): 349-355. [DOI] [PubMed]
13. Foroozanfard F, Talebi M, Samimi M, Mehrabi S, Badehnoosh B, Jamilian M, et al. Effect of two different doses of vitamin D supplementation on metabolic profiles of insulin-resistant patients with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial. Horm Metab Res 2017; 49(8): 612-7. [DOI] [PubMed]
14. Asemi Z, Foroozanfard F, Hashemi T, Bahmani F, Jamilian M, Esmaillzadeh A. Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Clin Nutr 2015; 34(4): 586-92. [DOI] [PubMed]
15. Misso ML, Teede HJ. Metformin in women with PCOS, cons. Endocrine 2015; 48(2): 428-33. [DOI] [PubMed]
16. Pasquali R. Metformin in women with PCOS, pros. Endocrine 2015; 48(2): 422-6. [DOI] [PubMed]

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