Volume 7, Issue 3 (Autumn 2003)                   J Qazvin Univ Med Sci 2003, 7(3): 17-22 | Back to browse issues page

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Sarkaki A, Alavian. The effects of unilateral electrolytic lesion of dorsal and lateral subdivisions of paragigantocellularis nucleus on pain score in rats. J Qazvin Univ Med Sci. 2003; 7 (3) :17-22
URL: http://journal.qums.ac.ir/article-1-222-en.html
Abstract:   (9959 Views)
Background: The paragigantocellularis nucleus (PGI) is a part of medullarypontine reticular formation which plays an important role in pain processing. Some investigations have shown that activation of PGI neurons causes inhibition of pain inputs received in the central nervous system. Objective: To determine the effects of unilateral electrolytic lesion of dorsal and lateral PGI nucleus on acute and chronic pain induced by formalin in rats. Methods: 30 NMRI male rats (200-250gr) in five groups (control, DPGI lesioned, LPGI lesioned and two sham lesioned groups) were used. Being anesthetized with ketamine hydrochloride (110mg/kg/ip), DPGI and LPGI subdivisions of rats’ brain were lesioned electrolyticaly under stereotaxic operation. Following the recovery of incision the rats’ acute and chronic pain score were evaluated by formalin test (50 l, 2.5%). Findings: Results showed that the lesion of dorsal-PGI affected neither acute nor chronic pain induced by formalin. Lesion of lateral-PGI did not affect acute pain, but increased chronic pain score significantly (P<0.02). Conclusion: It seems that dorsal-PGI neurons have no noticeable effect on pain score.
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Type of Study: Research | Subject: Physiology

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