Volume 16, Issue 2 (Summer 2012)                   J Qazvin Univ Med Sci 2012, 16(2): 52-57 | Back to browse issues page

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Mohebi A, Aghaei S, M. M, Tavakoli M. Prevalence of metallo-β-lactamase among imipenem-resistant Acinetobacter spp. isolated from selected hospitals in Karaj (2010). J Qazvin Univ Med Sci. 2012; 16 (2) :52-57
URL: http://journal.qums.ac.ir/article-1-1278-en.html
1- Qazvin University of Medical Sciences, Qazvin, Iran , Email: Q_m1984@yahoo.com
Abstract:   (7425 Views)


  Background : Imipenem-resistant Acinetobacter spp. resulting from metallo-β-lactamase (MBLs)-producing strains have been reported to be among important causes of nosocomial infections and of serious therapeutic problem worldwide.

  Objective : To determine the prevalence of metallo-β-lactamase among imipenem-resistant Acinetobacter isolates based on phenotypic methods.

  Methods : This was an descriptive study in which 140 clinical isolates of Acinetobacter spp. were initially tested for imipenem susceptibility and later for metallo-β-lactamase production using combined disk diffusion, double disk synergy test, and Hodge test during 2010. Antibiotic susceptibility of positive metallo-β-lactamase isolates were further evaluated by disk diffusion technique using CLSI methodology.

  Findings : Of 140 isolates, 29 (20.7%) were imipenem-resistant Acinetobacter. Positive phonetypic test for metallo-β-lactamase was 24 (17.1%).

  Conclusion : The result of this study is indicative of growing number of nosocomial infections associated with multidrug-resistant Acinetobacter spp. in this region leading to difficulties in antibiotic therapy.



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Type of Study: Research | Subject: Microbiology

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