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:: Volume 13, Issue 1 (Spring 2009) ::
J Qazvin Univ Med Sci 2009, 13(1): 29-33 Back to browse issues page
Vitamin D receptor gene BSMI polymorphisms in systemic lupus erythematosus and healthy subjects
M. Abbasi *, Z. Rezaie Yazdi , J. Tavakol Afshari , MR. Hatef , M. Sahebari , M. Yarjanli
, Email: mah.sky1348@yahoo.com
Abstract:   (6007 Views)
Background: Vitamin D receptor (VDR) gene polymorphisms cause functional differences in immunomodulatory action of vitamin D. An association between VDR gene BSMI polymorphisms and systemic lupus erythematosus (SLE) has been documented. Objective: To compare the VDR gene BSMI polymorphisms in patients with SLE and healthy controls. Methods: This was a case-control study conducted in the city of Mashhad (Iran). Sixty patients with lupus from two outpatient rheumatology clinics and 45 non-relative healthy controls of the same sex were selected using the census procedure. VDR gene typing was performed based on polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP). The results were analyzed using chi square test while a p<0.05 was considered as significant. Findings: The distribution of VDR genotyping of BSMI polymorphisms in patients with SLE were 23.3% for BB, 60% for Bb and 16.7% for bb. Similarly, the values found for healthy group were 33.3%, 46.7%, and 20% for BB, Bb, and bb, respectively. There was no statistically significant difference between two groups. Conclusion: No significant difference in relative frequency of VDR gene BSMI polymorphisms in SLE patients and healthy individuals was established.
Keywords: Keywords: Systemic lupus erythematosus, Polymorphisms, Vitamin D, BSMI gene, polymorphism
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Type of Study: Research | Subject: Internal Medicine
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Abbasi M, Rezaie Yazdi Z, Tavakol Afshari J, Hatef M, Sahebari M, Yarjanli M. Vitamin D receptor gene BSMI polymorphisms in systemic lupus erythematosus and healthy subjects. J Qazvin Univ Med Sci. 2009; 13 (1) :29-33
URL: http://journal.qums.ac.ir/article-1-797-en.html
Volume 13, Issue 1 (Spring 2009) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی قزوین The Journal of Qazvin University of Medical Sciences
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