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Abstract:   (232 Views)
Background: Preeclampsia is a complex disorder of pregnancy with an unknown cause. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases , in the development of the disease, but there are no definitive results.
Aim : The aim of this study was to investigate the possible association between (−1562C> T) rs 3918242 in the metalloproteinase-9 gene polymorphism with the risk of preeclampsia in pregnant women.
Materials and method: The genotypes −1562C> T in the metalloproteinase-9 gene polymorphism were investigated using polymerase chain reaction techniques and limited fragment length polymorphism method (PCR-RFLP). Logistic regression analysis was used to investigate the relationship between metaloproteinase-9 gene polymorphism with the risk of developing preeclampsia.
Results: The frequency of CC, CT, TT genotypes −1562C> T gene polymorphism of metaloproteinase-9 in the case group was 47.8%, 47.8% and 4.2%, and in the control group was 84.8, 13.1 and 2%, respectively. They were significant (P <0.001). The frequency of TT genotype in the patient group was significantly higher than the control group (P <0.001). Also, the prevalence of T allele in the patient group was 52.2% and in the control group was 15.2%, respectively which was a significant difference between the two groups (P <0.001).
Conclusion: This study showed that −1562C> T gene of metaloproteinase-9 polymorphism plays an important role as an independent factor in the incidence of preeclampsia.
Type of Study: Research | Subject: Biochemistry

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