Volume 22, Issue 5 (Dec - Jan 2018)                   J Qazvin Univ Med Sci 2018, 22(5): 80-86 | Back to browse issues page


XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Hosseinzadeh S, Allami A. Encephalitis/encephalopathy caused by H1N1 Influenza outbreak of 2017-2018 in Qazvin: A case report. J Qazvin Univ Med Sci. 2018; 22 (5) :80-86
URL: http://journal.qums.ac.ir/article-1-2613-en.html
Department of Infectious Diseases, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran , allami9@yahoo.com
Abstract:   (824 Views)
In some adults, infections result from influenza, which usually occurs as respiratory infections. In the central nervous system, influenza can cause aseptic meningitis and encephalitis/encephalopathy syndrome that may cause death or persistent brain complications. This report presents a case of encephalitis/encephalopathy caused by H1N1 virus in a 35-year-old man who was hospitalized with reduced consciousness and fever. The patient underwent empirical treatment of meningitis, acyclovir and oseltamivir. In the third day, the patient became alert at the hospital. The RT-PCR was positive for H1N1. In the cerebrospinal fluid sample, ten lymphocytes were seen, but protein and sugar were reported normal, and gram stain and culture were negative. Multiple punctate hyperintensities noted in subcortical white matter (in T2-weighted images of brain MRI) and EEG abnormality reported. Treatment with oseltamivir continued and patient was discharged with good general condition. Decreased level of consciousness can be due to influenza, especially during the epidemic.
Full-Text [PDF 129 kb]   (225 Downloads)    
Type of Study: case report | Subject: Infectious Disease

References
1. Maruyama T, Fujisawa T, Suga S, Nakamura H, Nagao M, Taniguchi K, et al. Outcomes and prognostic features of patients with influenza requiring hospitalization and receiving early antiviral therapy: a prospective multicenter cohort study. Chest 2016; 149(2): 526-34. [DOI] [PubMed]
2. Reed C, Chaves SS, Perez A, D'Mello T, Daily Kirley P, Aragon D, et al. Complications among adults hospitalized with influenza: a comparison of seasonal influenza and the 2009 H1N1 pandemic. Clin Infect Dis 2014; 59(2): 166-74. [DOI] [PubMed]
3. Wang GF, Li W, Li K. Acute encephalopathy and encephalitis caused by influenza virus infection. Curr Opin Neurol 2010; 23(3): 305-11. doi: 10.1097/WCO. 0b013e328338f6c9. [PubMed]
4. Alsolami A, Shiley K, editors. Successful treatment of Influenza-associated acute necrotizing encephalitis in an adult using high-dose oseltamivir and methylprednisolone: case report and literature review. Open Forum Infect Dis 2017; 4(3): ofx145. [DOI] [PubMed]
5. Toovey S. Influenza-associated central nervous system dysfunction: a literature review. Travel Med Infect Dis 2008; 6(3): 114-24. [DOI] [PubMed]
6. Morishima T, Togashi T, Yokota S, Okuno Y, Miyazaki C, Tashiro M, et al. Encephalitis and encephalopathy associated with an influenza epidemic in Japan. Clin Infect Dis 2002; 35(5): 512-7. [DOI] [PubMed]
7. Yoshikawa H, Yamazaki S, Watanabe T, Abe T. Study of influenza-associated encephalitis/encephalopathy in children during the 1997 to 2001 influenza seasons. J Child Neurol 2001; 16(12): 885-90. [DOI] [PubMed]
8. Lee N, Wong CK, Chan PK, Lindegardh N, White NJ, Hayden FG, et al. Acute encephalopathy associated with influenza a infection in adults. Emerg Infect Dis 2010; 16(1): 139-42. [DOI] [PubMed]
9. Babamahmoodi F, Afzalian Ashkezari E, Ahangarkani F, Davoodi L, Shirdel S. A case of encephalitis caused by H1N1 influenza outbreak of 2015 in North of Iran. J Mazandaran Univ Med Sci 2016; 26(139): 209-15. [In Persian]
10. Ahn SJ, Sunwoo JS, Lee HS, Lim JA, Moon J, Lee ST, et al. Screening of respiratory virus PCR panel in adults with CNS infection. Int J Infect Dis 2016; 53: 99. [DOI]

Add your comments about this article : Your username or Email:
CAPTCHA code

Send email to the article author


© 2019 All Rights Reserved | The Journal of Qazvin University of Medical Sciences

Designed & Developed by : Yektaweb