Volume 21, Issue 6 (Feb - Mar 2018)                   J Qazvin Univ Med Sci 2018, 21(6): 37-30 | Back to browse issues page

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Hajifathaliya Z, Najafipour R, Modarressi M, Savad S, Rashvand Z. Association between the HLA-G*0105N polymorphism and recurrent abortion in women. J Qazvin Univ Med Sci. 2018; 21 (6) :37-30
URL: http://journal.qums.ac.ir/article-1-2337-en.html
1- Tehran University of Medical Sciences
Abstract:   (1975 Views)

Background: In human pregnancies HLA-G (Human leukocyte antigens G) is supposed that play a main role in implantation. It is expressed on trophoblast cells that invades during pregnancy to the uterus decidua and is introduced to induce maternal tolerance immunologically against the fetus.
Objective: The aim of this study was to find association between the HLA-G*0105N polymorphism and recurrent abortion in women.
Methods: This case-control study was conducted on two groups of 108 women with history recurrent abortion (RSA) as a case group or without history RSA as a control group in Cellular and Molecular Research Center, Qazvin University of Medical Sciences in 2015. The frequency of null allele of HLA-G*0105N was studied in two groups by PCR -RFLP method. Allele and genotype frequencies of two group were compared using Hardy-Weinberg equilibrium and Chi-square test.
Findings: In case group, 54 (50%) and 17 (15.7%) were heterozygous and homozygous respectively for HLA-G*0105N polymorphism. In control group, only 9 (8%) was homozygous for HLA-G*0105N polymorphism. But there was no significant difference between case and control on HLA-G*0105N allele with RSA (P=0.1004).
Conclusion: As the results, there was no significant association between HLA-G*0105N poly morphism and RSA. Thus, it seems that this HLA-G*0105N polymorphism may effective in relation with other genes or polymorphisms in RSA.

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Type of Study: Research | Subject: Genetics

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