[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Search :: Archive :: Registration :: Submit :: Site Map :: Contact ::
:: Volume 20, Issue 4 (Oct _Nov 2016) ::
J Qazvin Univ Med Sci 2016, 20(4): 21-13 Back to browse issues page
The relationship between factor inhibiting HIF-1-alpha (HIF1AN) expression and vascular invasion in colon cancer
R. Najafipour , N. Rakhshani , L. Vakil *, F. Zamani , A. Morakabati , A. Javadi
Cellular and Molecular Research Center, Qazvin University of Medical Sciences, GI and Liver Disease Research Center, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran , ladanamor@gmail.com
Abstract:   (1447 Views)

Background: Hypoxia is a common phenomenon in human solid tumors which by increasing in angiogenesis induction cause tumor growth survival and metastasis.

Inhibitory factor hypoxia regulatory factor (HIF1AN) by binding to transcription co activators CBP/P300(, inhibits hypoxia inducible factor (HIF1α).

Objective: The relationship between HIF1AN expression and vascular invasion in colon tumors.

Methods: The study included 101 patients with colon adenocarcinoma which were divided to vascular invasion and non-vascular invasion groups. Tumor paraffin blocks were immunohistochemistry stained for HIF1AN and were assessed for intensity and extent of positivity.

Statistical relation of marker expression and clinic pathologic findings were assessed. Data were analyzed by SPSS 21 software and logistic regression and chi-square test.

Findings: Nuclear immunoreactivity of HIF1AN was different between two groups. Statistical relation between low HIF1AN expression and tumor vascular invasion were seen (P=0.01). No relation was found between tumor differentiation, depth and HIF1AN.

Conclusion: Evidence showed that the low expression or incorrect position of HIF1AN in nucleus of tumor cells was effective on HIF1α inhibition failure and factors associated angiogenesis increased. The HIF1AN played an tumor suppressor gene (TSG( role in colon tumors and decreased protein in the nucleus of colon cancer cells increased the expression of angiogenesis factors and vascular invasion.

Keywords: Angiogenesis, Vascular Invasion, HIF1AN, Colon Cancer
Full-Text [PDF 526 kb]   (495 Downloads)    
Type of Study: Research | Subject: Patology
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Najafipour R, Rakhshani N, Vakil L, Zamani F, Morakabati A, Javadi A. The relationship between factor inhibiting HIF-1-alpha (HIF1AN) expression and vascular invasion in colon cancer. J Qazvin Univ Med Sci. 2016; 20 (4) :21-13
URL: http://journal.qums.ac.ir/article-1-2106-en.html
Volume 20, Issue 4 (Oct _Nov 2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی قزوین The Journal of Qazvin University of Medical Sciences
Persian site map - English site map - Created in 0.101 seconds with 828 queries by yektaweb 3525