Volume 15, Issue 2 (Summer 2011)                   J Qazvin Univ Med Sci 2011, 15(2): 86-93 | Back to browse issues page

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Saffari F, Asgari A, sadeghi T, hajmanocheri F. Comparison of Hashimoto thyroiditis in patients with type 1 diabetes and controls . J Qazvin Univ Med Sci. 2011; 15 (2) :86-93
URL: http://journal.qums.ac.ir/article-1-1118-en.html
1- Qazvin University of Medical Sciences, Qazvin, Iran , Email: Drasgari1388@yahoo.com
2- Qazvin University of Medical Sciences, Qazvin, Iran
3- TUMS, Tehran, Iran
Abstract:   (7362 Views)
Background: Type 1 diabetes is the most common metabolic disease worldwide. Thyroid autoimmune diseases is the most common endocrinopathy in diabetes type 1 .Therefore, assessment of thyroid function tests and anti thyroid antibodies in diabetic patients (type 1) is beneficial in early. Objective: The purpose of this study was to compare the anti-thyroid antibodies in diabetic children (type 1) with healthy children . Methods: In this descriptive-analytic study, 65 children with Type 1 diabetes and 65 healthy children who had referred to Children's Hospital in Qazvin were selected by simple sampling. Anti-TG, Anti-TPO, TSH and T4 were measured in both groups. Chi-square, t-independent and Kruskal Valis was used for statistical analysis. Findings: The difference between sex and age in both groups (case and control) was not significant but BMI percentile was significantly different. Positive Anti-TG was 10.8% in patients and was 1.5% in controls .The difference was statistically significant (p=0.029). 16.9% of patients and 3.1% of controls had positive Anti-TPO (p=0.024).10.8% of patients had increased TSH and decreased T4 level (Overt Hypothyroidism) .4.6% of controls had increased TSH and normal T4 level (Subclinical Hypothyroidism). The difference was statistically significant for T4. Conclusion: It seems that the prevalence of Hashimoto thyroiditis in patients with type 1 diabetes is more than healthy people. Hence, evaluation of thyroid function tests (TFT) and antithyroid antibodies (Anti-TPO) is necessary to diagnosis and treatment of autoimmune thyroid disorders.
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Type of Study: Research | Subject: Pediatrics
Received: 2011/04/19

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